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Kinetic and mechanistic studies of proline-mediated direct intermolecular aldol reactions
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2009, Vol. 19 Issue 14, p3934-3937. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: Reaction progress kinetic analysis of the proline-mediated intermolecular aldol reaction shows that the rate depends on the concentrations of both the donor ketone1 and the electrophilic aldehyde 2, implying that enamine formation cannot be rate-determining. The observed kinetics and deuterium isotope effects are consistent with formation of the product iminium species as the rate-determining step. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 43175081
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.03.112