Peritoneal disease in breast cancer: A specific entity with an extremely poor prognosis

Abstract: Background: Peritoneal metastases are now a significant cause of morbidity and mortality in patients with advanced breast cancer. There are few published data regarding the prognosis, clinical characteristics and management of individuals with peritoneal metastases from breast cancer. Methods: The electronic database at Imperial College Healthcare NHS Trust (Charing Cross Hospital) was searched for the terms ‘breast’, ‘cancer’ or ‘tumour’, ‘peritoneal’ and ‘ascites’ from 2000 to 2008. Those with confirmed peritoneal disease from breast cancer, as described on ultrasound or staging CT reports with a clinico-pathologic confirmed diagnosis, were included. Results: A total of 1628 patients were screened and initially 168 patients were identified. A subsequent total of 44 individuals (2.7% of the cohort) were defined as having breast cancer with peritoneal secondaries and were included in the analysis. Of these, the majority (77%) had invasive ductal carcinomas (IDCs). While the median survival from the diagnosis of metastatic breast cancer measured 20.5 months (range 0.1–125 months), the median survival of patients with peritoneal disease was 1.56 months (range 0.2–27 months). Conclusions: These data demonstrate that the median survival of patients with peritoneal breast cancer metastasis is surprisingly poor, with only a minority surviving more than 6 months. A specific association with invasive lobular carcinoma (ILC) was not observed. The dismal outcome of these individuals, despite further active therapy, merits their inclusion into clinical trials designed specifically for this group of patients. [Copyright &y& Elsevier]