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Endothelin-1 Across the Lung Circulation in Patients With Pulmonary Arterial Hypertension and Influence of Epoprostenol Infusion
- Source :
-
Journal of Heart & Lung Transplantation . Aug2009, Vol. 28 Issue 8, p808-814. 7p. - Publication Year :
- 2009
-
Abstract
- Background: The endothelin-1 (ET-1) system plays a pathophysiologic role in patients with pulmonary arterial hypertension (PAH). Results from previous studies assessing the transpulmonary gradient of ET-1 have been inconsistent. The influence of an intravenous epoprostenol infusion on the transpulmonary ET-1 gradient is unknown. Methods: In a prospective investigation, serum concentrations of ET-1 were measured in 39 consecutive patients (31 women; mean age, 20–77 years) with pulmonary hypertension (33 with PAH) and compared with 20 controls. The effect of intravenous epoprostenol administration on the transpulmonary gradient of ET-1 was analyzed in 13 patients with pulmonary hypertension. Blood samples were taken simultaneously from the pulmonary artery and radial artery. Results: The serum levels of ET-1 were significantly higher in the arterial (3.9 ± 1.28 vs 2.53 ± 0.24 pg/ml, p < 0.001) and mixed venous blood samples (3.9 ± 1.21 vs 2.52 ± 0.29 pg/ml, p < 0.001) in patients with pulmonary hypertension than in controls. The arterial/venous ratio of ET-1 in patients (1.0 ± 0.1) and in the control group (1.0 ± 0.05) was similar (p = 0.79). During intravenous epoprostenol infusion, there were no changes in the mean transpulmonary ET-1 gradient (0.98 ± 0.07 vs 0.96 ± 0.09, p = 0.52), despite significant hemodynamic changes. Conclusion: The ET-1 radial artery/pulmonary artery ratio of unity indicates a balanced release and clearance of ET-1 across the lung circulation in controls and in patients with different forms of pulmonary hypertension. ET-1 levels across the pulmonary circulation did not change during epoprostenol infusion. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10532498
- Volume :
- 28
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Heart & Lung Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 43409924
- Full Text :
- https://doi.org/10.1016/j.healun.2009.04.017