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Cytokine Array Comparisons of Plasma from Cycling Fertile Women on Cycle Day 5 and Ovulation.
- Source :
-
American Journal of Reproductive Immunology . Sep2009, Vol. 62 Issue 3, p158-164. 7p. 1 Black and White Photograph, 1 Diagram, 3 Charts. - Publication Year :
- 2009
-
Abstract
- Problem To identify plasma immuno-regulatory molecules up or down regulated between the follicular phase and ovulation of the human menstrual cycle. Method of study RayBio® cytokine arrays were used to screen 174 immuno-regulatory molecules in plasma collected during the follicular phase at menstrual cycle day 5 and at ovulation from five healthy, non-smoking, fertile women of reproductive age not using hormonal contraception. Results A total of 23 differentially expressed molecules were found: 10 molecules were differentially up-regulated and 13 down-regulated at ovulation compared with that at the follicular phase (α = 0.05, false discovery rate of 0.45). Conclusion Circulating immuno-regulatory molecules fluctuate over the menstrual cycle in healthy women. The combination of differentially expressed molecules suggests roles in cyclical regulation of angiogenesis and immune cell trafficking. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MENSTRUAL cycle
*BLOOD plasma
*MOLECULES
*WOMEN'S health
*NEOVASCULARIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 10467408
- Volume :
- 62
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- American Journal of Reproductive Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 43668625
- Full Text :
- https://doi.org/10.1111/j.1600-0897.2009.00725.x