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Mammary tumors with diverse immunological phenotypes show differing sensitivity to adoptively transferred CD8+ T cells lacking the Cbl-b gene.
- Source :
-
Cancer Immunology, Immunotherapy . Nov2009, Vol. 58 Issue 11, p1867-1877. 11p. 1 Color Photograph, 1 Chart, 3 Graphs. - Publication Year :
- 2009
-
Abstract
- We tested the efficacy of CD8+ T cells lacking the Cbl-b gene against a panel of mammary tumor lines with different intrinsic sensitivities to T cells. Mice bearing established tumors expressing an ovalbumin-tagged version of HER-2/ neu underwent adoptive transfer with Cbl-b-replete or -null CD8+ T cells from OT-I T cell receptor transgenic donor mice. In general, Cbl-b-null OT-I cells showed enhanced expansion, persistence, and capacity for tumor infiltration. This resulted in markedly enhanced efficacy against two tumor lines that normally demonstrate complete (NOP21) or partial (NOP23) regression. Moreover, a third tumor line (NOP6) that normally demonstrates progressive disease underwent complete regression in response to Cbl-b-null OT-I cells. However, a fourth tumor line (NOP18) was resistant to Cbl-b-null OT-I cells owing to a profound barrier to lymphocyte infiltration. Thus, Cbl-b-null CD8+ T cells are generally more efficacious but are nonetheless unable to mediate curative responses against all tumor phenotypes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MAMMARY gland cancer
*TUMORS
*T cells
*LYMPHOCYTES
*CANCER treatment
Subjects
Details
- Language :
- English
- ISSN :
- 03407004
- Volume :
- 58
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Cancer Immunology, Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 43757711
- Full Text :
- https://doi.org/10.1007/s00262-009-0698-3