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Studies towards topical selective β2-adrenoceptor agonists with a long duration of action
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Sep2009, Vol. 19 Issue 17, p5237-5240. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: β2-Adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The compounds exhibited a high potency in a functional cellular assay and a bronchoprotective effect in a guinea pig model which lasted over the complete study period of 5h. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 43767346
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.06.104