Cyclic oligomers (macroaldonolactones) from a protected d-galactonic acid monomer

Authors :: Lorena Romero Zaliz, C.
Varela, Oscar
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Oct2009, Vol. 50 Issue 40, p5677-5680. 4p.
Publication Year :: 2009
Abstract: Abstract: Dicyclohexylcarbodiimide-promoted self-condensation of 2,3:4,5-di-O-isopropylidene-d-galactonic acid (3) led to the macrocyclic oligomeric cyclo[(2,3:4,5-di-O-isopropylidene-(1→6)-d-galactonate)2] (4) and cyclo[(2,3:4,5-di-O-isopropylidene-(1→6)-d-galactonate)3] (5), having, respectively, 14- and 21-membered rings. The macrocycles 4 and 5 were also synthesized by cyclization of the respective linear dimer 11 and trimer 14 ω-hydroxy acids precursors prepared by stepwise additions of 3. Compounds 4 and 5 are biomaterials that may be described as macrolactone-cyclodextrins. [Copyright &y& Elsevier]

Subjects :: *LACTONES
*OLIGOMERS
*CARBOXYLIC acids
*MONOMERS
*IMIDES
*CONDENSATION
*RING formation (Chemistry)
*ORGANIC synthesis
*CYCLODEXTRINS

Language :: English
ISSN :: 00404039
Volume :: 50
Issue :: 40
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 43870751
Full Text :: https://doi.org/10.1016/j.tetlet.2009.07.123

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