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Hippocampal Replay of Extended Experience
- Source :
-
Neuron . Aug2009, Vol. 63 Issue 4, p497-507. 11p. - Publication Year :
- 2009
-
Abstract
- Summary: During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences corresponding to recent spatial experience. Such “replay” co-occurs with ripple events: short-lasting (∼50–120 ms), high-frequency (∼200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats exploring small environments showed replay anchored to the rat''s current location and compressed in time into a single ripple event. Here, we show, using a neural decoding approach, that firing sequences corresponding to long runs through a large environment are replayed with high fidelity and that such replay can begin at remote locations on the track. Extended replay proceeds at a characteristic virtual speed of ∼8 m/s and remains coherent across trains of ripple events. These results suggest that extended replay is composed of chains of shorter subsequences, which may reflect a strategy for the storage and flexible expression of memories of prolonged experience. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08966273
- Volume :
- 63
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 43871981
- Full Text :
- https://doi.org/10.1016/j.neuron.2009.07.027