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A convenient, high-yield synthesis of 1-substituted uracil and thymine derivatives
- Source :
-
Tetrahedron . Oct2009, Vol. 65 Issue 41, p8513-8523. 11p. - Publication Year :
- 2009
-
Abstract
- Abstract: Novel reagents for the synthesis of 1-substituted uracil and thymine derivatives have been developed. The aminolysis of 2- or 4-nitrophenyl 3-ethoxyacryloylcarbamate and 3-ethoxy-2-methylacryloylcarbamate with a variety of primary amino derivatives proceeded smoothly under very mild reaction conditions yielding almost quantitatively the 1,3-disubstituted urea derivatives. Their subsequent cyclization provided the 1-substituted uracil and thymine compounds, in almost quantitative yield. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 65
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 44101253
- Full Text :
- https://doi.org/10.1016/j.tet.2009.08.019