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Expression and Hormonal Regulation of IL-11Rα in Canine Uterus During Early Pregnancy.
- Source :
-
Reproduction in Domestic Animals . Oct2009, Vol. 44 Issue 5, p779-782. 4p. 3 Diagrams. - Publication Year :
- 2009
-
Abstract
- Contents Embryo implantation is critical for the successful establishment of pregnancy. Interleukin-11 (IL-11) is essential for adequate decidualization in the mouse and human via binding to the specific IL-11 receptor α (IL-11Rα). But the expression and regulation of IL-11 and IL-11Rα in the canine endometrium remain unknown. The aim of this study was to investigate the differential expression of IL-11Rα in canine uterus during early pregnancy and its regulation under different conditions by in situ hybridization. Interleukin-11Rα mRNA was mainly localized in glandular epithelium in canine uterus. There was a low level of IL-11Rα expression in the glandular epithelium on days 6, 12 and 17 of pregnancy. On day 20 of pregnancy when embryo implanted, IL-11Rα mRNA was highly expressed in the glandular epithelium surrounding the embryo, but not in the luminal epithelium and stroma. On day 23 of pregnancy, the expression of IL-11Rα mRNA maintained a constant level compared with the expression of day 20 and increased on day 28 of pregnancy. During the oestrous cycle, a high level of IL-11Rα mRNA expression was seen in the oestrous uterus. Progesterone slightly induced the expression of IL-11Rα mRNA in the ovariectomized canine uterus. These results suggest that IL-11Rα expression is closely related to canine implantation and up-regulated by progesterone. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PREGNANCY
*UTERUS
*INTERLEUKINS
*IN situ hybridization
*ENDOMETRIUM
Subjects
Details
- Language :
- English
- ISSN :
- 09366768
- Volume :
- 44
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Reproduction in Domestic Animals
- Publication Type :
- Academic Journal
- Accession number :
- 44193276
- Full Text :
- https://doi.org/10.1111/j.1439-0531.2008.01072.x