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An Efficient Route to 2-Substituted N-(1-Amino-3-methylpyrrol)amides by Ring-Opening Cyclization of Benzylidene- and Alkylidenecyclopropylcarbaldehydes with Hydrazides.
- Source :
-
Journal of Organic Chemistry . 8/21/2009, Vol. 74 Issue 16, p5983-5986. 4p. 3 Charts. - Publication Year :
- 2009
-
Abstract
- A convenient and efficient synthetic method for the construction of 2,3-disubstituted pyrrolamides in moderate to good yields is established. The in situ generated water significantly accelerates the reaction rate. A possible mechanism involving the cascade ring-opening and thermal-induced rearrangement to produce the five-membered ring is proposed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 74
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 44221435
- Full Text :
- https://doi.org/10.1021/jo900730t