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High-Affinity Peptide-Based Collagen Targeting Using Synthetic Phage Mimics: From Phage Display to Dendrimer Display.

Authors :
Helms, Brett A.
Reulen, Sanne W. A.
Nijhuis, Sebastiaan
de Graaf-Heuvelmans, Peggy T. H. M.
Merkx, Maarten
Meijer, E. W.
Source :
Journal of the American Chemical Society. 8/26/2009, Vol. 131 Issue 33, p11683-11685. 3p.
Publication Year :
2009

Abstract

The article presents a research regarding the implementation of synthetic phage mimics for targeting of peptide-based collagen. It notes that enhancement of high-affinity peptides driven by phage-display is preformed by a multivalent approach. In conclusion, the advantages of the strength of biological display methods and ability to deliver a wide variety of functional groups are emphasized in the study.

Details

Language :
English
ISSN :
00027863
Volume :
131
Issue :
33
Database :
Academic Search Index
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
44222931
Full Text :
https://doi.org/10.1021/ja902285m