Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs.

Authors :: Korpisalo, Petra
Rissanen, Tuomas T.
Bengtsson, Timo
Liimatainen, Timo
Laidinen, Svetlana
Karvinen, Henna
Markkanen, Johanna E.
Gröhn, Olli H.
Ylä-Herttuala, Seppo
Source :: Cardiovascular Research. Nov2008, Vol. 80 Issue 2, p263-270. 8p. 1 Color Photograph, 1 Diagram, 5 Graphs.
Publication Year :: 2008
Abstract: Aims: We investigated the effects of angiogenic gene therapy with adenoviral placental growth factor131 (AdPlGF) on aerobic capacity and exercise tolerance in a rabbit hindlimb ischaemia model. We also assessed whether strong angiogenic changes such as capillary arterialization and formation of artery-venous shunts compromise oxygen transport to target tissues resulting in suboptimal therapeutic efficacy. [ABSTRACT FROM PUBLISHER]

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