Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy.

Authors :: Jing Xiao
Leung, Joseph C. K.
Chan, Loretta Y. Y.
Hong Guo
Kar Neng Lai
Source :: Nephrology Dialysis Transplantation. Jul2009, Vol. 24 Issue 7, p2067-2077. 11p. 1 Chart, 7 Graphs.
Publication Year :: 2009
Abstract: Background. We have previously demonstrated a glomerulo-tubular ‘crosstalk’ operating in the pathogenesis of tubulointerstitial injury in IgA nephropathy (IgAN). The present study aims to explore any possible beneficial effect of a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist in alleviating the tubulointerstitial inflammation in IgAN. [ABSTRACT FROM PUBLISHER]

Subjects :: *ANGIOTENSIN II
*IMMUNOGLOBULIN A
*IGA glomerulonephritis
*KIDNEY diseases
*KIDNEY glomerulus

Full Text Access

Tools