Point Mutations of the mtDNA Control Region in Normal and Neurodegenerative Human Brains.

Authors :: Chinnery, P. F.
Brown, D. T.
Taylor, G. A.
Howell, N.
Parsons, T. J.
Turnbull, D. M.
Source :: American Journal of Human Genetics. Feb2001, Vol. 68 Issue 2, p529-532. 4p. 1 Diagram.
Publication Year :: 2001
Abstract: Studies the mitochondrial DNA control region in human brain tissues of normal elderly individuals and individuals with neurodegenerative disease to investigate the role of mitochondrial DNA mutations in aging. Position of the sequence changes seen in brain tissues of the individuals; Technique for the detection of low levels of mitochondrial DNA heteroplasmy; Possibilities for not detecting some of the mitochondrial DNA mutations.

Subjects :: *NEURODEGENERATION
*MITOCHONDRIAL DNA
*GENETICS of aging
*GENETIC mutation

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