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Lysosomes as "Suicide Bags" in Cell Death: Myth or Reality?

Authors :
Turk, Boris
Turk, Vito
Source :
Journal of Biological Chemistry. 8/14/2009, Vol. 284 Issue 33, p21783-21787. 5p. 1 Chart.
Publication Year :
2009

Abstract

The article discusses the suicidal roles of lysosomes, that are described as suicide bags, in cellular processes. It states that lysosomes are linked to three major morphologically distinct pathways of cell death including apoptosis, type II programmed cell death or autophagic cell death, and necrosis. Furthermore, it mentions that lysosomes, regardless of their destructive potential, should not be called suicide bags because cell death happens mainly during pathologies.

Details

Language :
English
ISSN :
00219258
Volume :
284
Issue :
33
Database :
Academic Search Index
Journal :
Journal of Biological Chemistry
Publication Type :
Academic Journal
Accession number :
44477396
Full Text :
https://doi.org/10.1074/jbc.R109.023820