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Molecular Character of the Recombinant Antitumor Lectin from the Edible Mushroom Agrocybe aegerita.
- Source :
-
Journal of Biochemistry . Aug2005, Vol. 138 Issue 2, p145-150. 6p. - Publication Year :
- 2005
-
Abstract
- The lectin from Agrocybe aegerita (AAL) has been found to possess potent tumor-suppressing function and tumor cell apoptosis-inducing activity. In this paper, we report the full sequence, the active expression of the gene encoding AAL at a high level and bioassay of the binding property with lactose, apoptosis-inducing activity and DNase activity of recombinant AAL (rAAL). The results reveal that AAL is a member of the galectin family and the dimeric form is the active unit for the functional performance. The rAAL showed comparable tumor cell apoptosis-inducing activity with the wild AAL but no DNase activity at all. The molecular characters revealed by this study are significant for the in-depth investigation of the functional mechanism of this interesting protein. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *LECTINS
*CANCER cells
*CELLULAR pathology
*APOPTOSIS
*CELL death
Subjects
Details
- Language :
- English
- ISSN :
- 0021924X
- Volume :
- 138
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 44543699
- Full Text :
- https://doi.org/10.1093/jb/mvi109