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Donor KIR3DL1/3DS1 Gene and Recipient Bw4 KIR Ligand as Prognostic Markers for Outcome in Unrelated Hematopoietic Stem Cell Transplantation

Authors :
Gagne, Katia
Busson, Marc
Bignon, Jean-Denis
Balère-Appert, Marie-Lorraine
Loiseau, Pascale
Dormoy, Anne
Dubois, Valérie
Perrier, Pascale
Jollet, Isabelle
Bois, Monique
Masson, Dominique
Moine, Agnès
Absi, Léna
Blaise, Didier
Charron, Dominique
Raffoux, Colette
Source :
Biology of Blood & Marrow Transplantation. Nov2009, Vol. 15 Issue 11, p1366-1375. 10p.
Publication Year :
2009

Abstract

Given their antileukemic activity, natural killer (NK) cells can alter the outcome of hematopoietic stem cell transplantation (HSCT). The physiologic functions of NK cells are regulated by the interaction of killer immunoglobulin-like receptors (KIR) with specific HLA class I ligands. In the literature, different models based on HLA class I and/or KIR donor (D)/recipient (R) gene disparities are considered as predictors of NK cell alloreactivity. In this retrospective and multicentric French study, we analyzed the clinical impact of the different NK-alloreactivity models in 264 patients who underwent T repleted unrelated HSCT. First, we did not observe that the “KIR ligand-ligand” model had a significant clinical impact on unrelated HSCT outcome, whereas the “missing KIR ligand” model had a significant but limited effect on unrelated HSCT, because only the absence of C1 ligand in patients with myelogenous diseases was associated with a decreased overall survival (OS) (hazard ratio=2.17, P =.005). The “KIR receptor-receptor” and the “KIR receptor-ligand” models seemed the most capable of predicting NK alloreactivity because they had a significant impact on acute graft-versus-host disease (aGVHD) occurrence, OS, and relapse incidence in D/R unrelated pairs. In particular, KIR3DL1 gene mismatches in the GVH direction (D+R−) and the D KIR3DL1+/3DS1+ and R Bw4− combination were respectively correlated with the lowest OS in HLA identical pairs (HR=1.99, P =.02) and the highest incidence of relapse in HLA nonidentical D/R unrelated pairs (HR=4.72, P =.03). Overall, our results suggest a detrimental effect of KIR3DL1+/3DS1+ donor NK cells transplanted into HLA-Bw4− patients in the absence of an educational process via KIR3DL1/HLA-Bw4 interactions. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
10838791
Volume :
15
Issue :
11
Database :
Academic Search Index
Journal :
Biology of Blood & Marrow Transplantation
Publication Type :
Academic Journal
Accession number :
44584865
Full Text :
https://doi.org/10.1016/j.bbmt.2009.06.015