Back to Search
Start Over
Expression of calcitonin receptor-like receptor in human vascular tumours.
- Source :
-
Journal of Clinical Pathology . Oct2006, Vol. 59 Issue 10, p1104-1107. 4p. - Publication Year :
- 2006
-
Abstract
- BACKGROUND: Vascular tumours such as Kaposi’s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis. Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours. METHODS: CRLR expression was investigated in several specimens of Kaposi’s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction. RESULTS: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium. CONCLUSIONS: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219746
- Volume :
- 59
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 44661325
- Full Text :
- https://doi.org/10.1136/jcp.2005.026930