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Expression of calcitonin receptor-like receptor in human vascular tumours.

Authors :
S Hagner
Source :
Journal of Clinical Pathology. Oct2006, Vol. 59 Issue 10, p1104-1107. 4p.
Publication Year :
2006

Abstract

BACKGROUND: Vascular tumours such as Kaposi’s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis. Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours. METHODS: CRLR expression was investigated in several specimens of Kaposi’s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction. RESULTS: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium. CONCLUSIONS: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00219746
Volume :
59
Issue :
10
Database :
Academic Search Index
Journal :
Journal of Clinical Pathology
Publication Type :
Academic Journal
Accession number :
44661325
Full Text :
https://doi.org/10.1136/jcp.2005.026930