Back to Search
Start Over
Copper(II), palladium(II) and platinum(II) chloride complexes with 5-amino-2-tert-butyltetrazole: Synthesis, characterization and cytotoxicity
- Source :
-
Polyhedron . Nov2009, Vol. 28 Issue 16, p3614-3620. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: Complexes CuL3Cl2, PdL2Cl2 and PtL2Cl2, where L is a novel ligand from the series of 2-substituted 5-aminotetrazoles, namely 5-amino-2-tert-butyltetrazole (1), have been synthesized by the reaction of metal(II) chlorides with 1 and characterized by IR spectroscopy, thermal and X-ray analyses. The crystallographic structural analysis of these complexes revealed that 1 acts as a monodentate ligand coordinated to the metal via endocyclic N4 atom. Platinum complex demonstrates promising cytotoxicity against human cervical carcinoma cells with IC50 value average between those of cisplatin and carboplatin. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02775387
- Volume :
- 28
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Polyhedron
- Publication Type :
- Academic Journal
- Accession number :
- 44699151
- Full Text :
- https://doi.org/10.1016/j.poly.2009.07.054