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Effects of NT-4 gene modified fibroblasts transplanted into AD rats
- Source :
-
Neuroscience Letters . Nov2009, Vol. 466 Issue 1, p1-5. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: It is well known that fibroblasts can act as a cell vector to express functional protein, like neurotrophin-4 (NT-4). The present study evaluated the effect of NT-4 gene modified fibroblasts grafted into the hippocampus of AD rat model. AD rats were reproduced by bilateral transection of the hippocampal fimbria-fornix. The transplanted fibroblasts steadily expressed NT-4 proteins at least 2 months after transplantation. This correlated with a significant rescue in the number of cholinergic neurons in the host hippocampus. Morris water maze tests demonstrated significant improvements in learning and memory, especially in rats receiving NT-4-modified fibroblasts. The present results showed that NT-4 gene modified fibroblasts could provide a long-term and steady expression of NT-4, and it significantly improved the behavior of AD rats. These findings should have important clinical applications in providing a long-term NT-4 Secretion for the treatment of AD. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 466
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 44699420
- Full Text :
- https://doi.org/10.1016/j.neulet.2009.09.020