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Novel Orthogonal Synthesis of a Tagged Combinatorial Triazine Library via Grignard Reaction.
- Source :
-
Australian Journal of Chemistry . Sep2009, Vol. 62 Issue 9, p1000-1006. 7p. - Publication Year :
- 2009
-
Abstract
- To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the C–C bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00049425
- Volume :
- 62
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Australian Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 44738939
- Full Text :
- https://doi.org/10.1071/CH09153