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Plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) Correlations With Cystatin C, Serum Creatinine, and Glomerular Filtration Rate in Patients After Heart and Lung Transplantation
- Source :
-
Transplantation Proceedings . Oct2009, Vol. 41 Issue 8, p3242-3243. 2p. - Publication Year :
- 2009
-
Abstract
- Abstract: Objective: Kidney injury represents a major clinical problem in orthotopic heart transplant (OHT) patients which seriously increases the mortality rate. The aim of this work was to evaluate the utility of a new kidney damage marker—neutrophil gelatinase-associated lipocalin (NGAL)—and its correlations with cystatin C, creatinine, and glomerular filtration rate (GFR) among patients after heart or lung transplantation. Materials and Methods: We examined serum samples from 71 patients after heart transplantation, 7 patients after lung transplantation, and 20 healthy controls to measure serum NGAL using an enzyme-linked immunosorbent assay (ELISA) method; cystatin C using latex immunonephelometry; and creatinine using the alkaline-picrate method. Results: Serum NGAL levels were significantly elevated among transplant patients, but did not significantly correlate with cystatin C in the transplant group (R = .13; P = .11) or in the control group (R = .26; P = .26), or GFR in the transplant group (R = −.09; P = .25) or in the control cohort (R = .22; P = .36). In the transplant group, serum NGAL positively correlated with serum creatinine (R = .27; P = .001). Conclusions: Plasma NGAL was not a specific biomarker for monitoring chronic renal disorders. We did not exclude other pathologies that might contribute to increased serum NGAL levels. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00411345
- Volume :
- 41
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Transplantation Proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 44827403
- Full Text :
- https://doi.org/10.1016/j.transproceed.2009.08.018