Vulnerability of Synaptosomes from ApoE Knock-Out Mice to Structural and Oxidative Modifications....

Authors :: Lauderback, Christopher M.
Hackett, Janna M.
Keller, Jeffrey N.
Varadarajan, Sridhar
Szweda, Luke
Kindy, Mark
Markesbery, William R.
Butterfield, D. Allan
Source :: Biochemistry. 02/27/2001, Vol. 40 Issue 8, p2548. 7p. 1 Diagram, 7 Graphs.
Publication Year :: 2001
Abstract: Examines the role of apolipoprotein E (apoE) in the neurodegeneration and increased lipid peroxidation in transgenic mice. Role of apoE in the induction of oxidative injury and maintenance of synaptic integrity; Major risk factor for Alzheimer's disease.

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