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Anti-complementary effect of polysacchride B3-PS1 in Herba Scutellariae Barbatae ( Scutellaria barbata).
- Source :
-
Immunopharmacology & Immunotoxicology . Dec2009, Vol. 31 Issue 4, p696-701. 6p. - Publication Year :
- 2009
-
Abstract
- The polysaccharide B3-PS1 was extracted and purified from Herba Scutellariae Barbatae ( Scutellaria barbata D. Don), through bioactivity-guided fractionation. Average molecular weight of B3-PS1 was about 1,700,000 Da with a composition of Gal, Glc, Man and Ara in the ratio of 4.3:1.6:1.1:1.0, and trace of Rha, Fuc and Xyl. Preliminary data showed that 1) B3-PS1 inhibited complement activation of the classic pathway with CH50 value of 0.12 ± 0.02 mg/ml and of the alternative pathways with AP50 value of 0.36 ± 0.05 mg/ml; 2) B3-PS1 interacts with C1q, C1r, C1s, C2, C3, C4, C5 and C9 through a hemolytic assay. These results strongly suggested that B3-PS1 could be a potential candidate in treating those complement-associated diseases such as rheumatoid arthritis, Alzheimer’s disease, and Adult Respiratory Distress Syndrome (ARDS). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08923973
- Volume :
- 31
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Immunopharmacology & Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 44891524
- Full Text :
- https://doi.org/10.3109/08923970903095314