ASPECTE CLINICO-BIOLOGICE ŞI EVOLUTIVE ÎN BETA-TALASEMIA MINORĂ.

The purpose of this paper is to highlight the important criteria in the diagnostic of minor forms of beta thalassemia. The study has been conducted on a number of 15 patients diagnosed with minor beta thalassemia at the Clinical Center for Diagnostic and Treatment and in a family clinic. The results have shown for each of the cases a significant drop in the values of mean corpuscular volume (VEM) (65,77±3,36 fl) and mean corpuscular hemoglobin (HEM) (20,69±1,2 pg), in contrast with the severity of the anaemia, all patients presenting light forms of anaemia (mean hemoglobin=11,55±1,05 g/dl). 40% of the patients had normal values of the mean corpuscular hemoglobin concentration and 46,6% of the patients had shown polyglobulie. All patients had raised values of Hb A2, this being the criteria to be included in the study. Most of the patients (53%) have undergone - previous to being diagnosed - treatments with iron. In conclusion, expressed hipocromia and microcitosis, unlike with the level of anaemia and the resistance to repeated treatment with iron, should draw our attention and make us analyse the possibility of the presence of a minor form of beta thalassemia. [ABSTRACT FROM AUTHOR]