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Activation of M2 muscarinic receptors leads to sustained suppression of hippocampal transmission in the medial prefrontal cortex.

Authors :
Wang, Lang
Yuan, Li-Lian
Source :
Journal of Physiology. Nov2009, Vol. 587 Issue 21, p5139-5147. 9p. 4 Graphs.
Publication Year :
2009

Abstract

Cholinergic innervation of the prefrontal cortex is critically involved in arousal, learning and memory. Dysfunction of muscarinic acetylcholine receptors and their downstream signalling pathways has been identified in mental retardation. To assess the role played by the muscarinic receptors at the hippocampal–frontal cortex synapses, an important relay in information storage, we used a newly developed frontal slice preparation in which hippocampal afferent fibres are preserved. Transient activation of muscarinic receptors by carbachol results in a long-lasting depression of synaptic efficacy at the hippocampal but not cortical pathways or local circuitry. On the basis of a combination of electrophysiological, pharmacological and anatomical results, this input-specific muscarinic modulation can be partially attributed to the M2 subtype of muscarinic receptors, possibly through a combination of pre- and postsynaptic mechanisms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00223751
Volume :
587
Issue :
21
Database :
Academic Search Index
Journal :
Journal of Physiology
Publication Type :
Academic Journal
Accession number :
44910403
Full Text :
https://doi.org/10.1113/jphysiol.2009.174821