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Bone maturation in extremely low birth weight infants in relation to birth weight and endocrine parameters.
- Source :
-
European Journal of Pediatrics . Dec2009, Vol. 168 Issue 12, p1497-1503. 7p. 4 Charts, 3 Graphs. - Publication Year :
- 2009
-
Abstract
- Modern intensive care techniques have led to higher survival rates of extremely low birth weight infants (ELBW, birth weight <1,000 g). Previous studies have suggested a link between abnormal birth parameters and subsequent endocrine disturbances, but a possible impact on bone maturation during childhood has not been studied. ELBW children were studied (mean chronological age (CA), 6.01 years; range, 4.5-8.2). Skeletal maturation was assessed according to Greulich and Pyle (8). Bone age (BA) was defined as retarded when DeltaBA-CA was < -1 SD and accelerated when DeltaBA-CA was >+1 SD. BA was either retarded or accelerated in 15 patients (24.6%). Twenty-one of 61 radiograms (34.4%) showed a discordant BA with a marked gender difference (14/24 boys; 7/37 girls). DeltaBA-CA correlated significantly with BMI (r = 0.36; p = 0.005) and height SDS (r = 0.35; p = 0.006). We found significant correlations between BA and androgens. Insulin-like growth factor binding protein-1 (IGFBP-1), which decreases in insulin-resistant individuals, correlated negatively with BA. In conclusion, bone maturation in ELBW children is correlative with height and weight. It is modulated by a variety of metabolic factors, including IGFBP-1 and androgens. Bone age, together with height and weight catch-up, can thus possibly serve as early indicators of insulin resistance later in life. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LOW birth weight
*BONE growth
*INFANT health
*INSULIN
*ENDOCRINE glands
*BIRTH weight
*CARRIER proteins
*COMPARATIVE studies
*DEHYDROEPIANDROSTERONE
*INSULIN resistance
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*SEX distribution
*SKELETAL maturity
*EVALUATION research
*BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 168
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 44930485
- Full Text :
- https://doi.org/10.1007/s00431-009-0962-8