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Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin–dextran as a novel MRI contrast agent
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2009, Vol. 19 Issue 23, p6675-6678. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: 5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R 1) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 45068331
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.10.003