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Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2009, Vol. 19 Issue 23, p6691-6695. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src-family kinases (SFKs). These type II inhibitors were optimized using a cellular Lck-dependent proliferation assay and are capable of inhibiting Lck at single-digit nanomolar concentrations. This scaffold is likely to serve a valuable template for developing potent inhibitors of a number of SFKs. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 45068335
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.09.123