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Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL-12.
- Source :
-
Immunology & Cell Biology . Nov/Dec2009, Vol. 87 Issue 8, p590-600. 11p. 1 Chart, 6 Graphs. - Publication Year :
- 2009
-
Abstract
- T follicular helper (TFH) cells are a specialized subset of CD4+ T cells that localize to B-cell follicles, where they are positioned to provide help for the induction of optimal humoral immune responses. Key features of TFH cells are the expressions of CXCR5, ICOS, interleukin (IL)-21 and BCL-6. The requirements for human TFH cell development are unknown. Here we show that IL-6, IL-12, IL-21 and IL-23 are capable of inducing IL-21 expression in naïve CD4+ T cells isolated from human tonsils, peripheral blood and cord blood. However, only IL-12 induced sustained expressions of CXCR5 and ICOS on these activated naïve CD4+ T cells, and endowed them with the ability to provide increased help to B cells for their differentiation into immunoglobulin-secreting cells. The effects of IL-12 were independent of interferon-γ and T-bet, and associated with upregulation of BCL-6 expression. Thus, these cytokines, particularly IL-12, are likely to act at an early stage during dendritic cell-mediated priming of naïve CD4+ T cells into a TFH cell fate, and thus underpin antibody-mediated immunity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*LYMPHOCYTES
*IMMUNOREGULATION
*ANTINEOPLASTIC agents
*DENDRITIC cells
Subjects
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 87
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 45117867
- Full Text :
- https://doi.org/10.1038/icb.2009.64