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Pyridinium Ylide-Assisted One-Pot Two-Step Tandem Synthesis of Polysubstituted Cyclopropanes.
- Source :
-
Journal of Combinatorial Chemistry . Nov2009, Vol. 11 Issue 6, p1007-1010. 4p. - Publication Year :
- 2009
-
Abstract
- A sequential one-pot two-step tandem reaction for efficient synthesis of polysubstituted cyclopropanes has been developed. The three-component reaction of α-halogenated methylene compounds, aromatic aldehydes, and acetonitrile derivatives produced first the intermediates pyridinium salts and electron-deficient olefins, followed by cyclopropanation of pyridinium ylide with electron-deficient olefins in situ to afford polysubstituted cyclopropanes. Target compounds were obtained in high yields and were diastereomerically pure after recrystallization. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15204766
- Volume :
- 11
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Combinatorial Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 45121683
- Full Text :
- https://doi.org/10.1021/cc900005v