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A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights.
- Source :
-
Organic Letters . Nov2009, Vol. 11 Issue 22, p5170-5173. 4p. - Publication Year :
- 2009
-
Abstract
- Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhizaBunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 11
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 45201307
- Full Text :
- https://doi.org/10.1021/ol902051v