Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles

Authors :: Ni, Chuanfa
Hu, Jinbo
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2009, Vol. 50 Issue 52, p7252-7255. 4p.
Publication Year :: 2009
Abstract: Abstract: A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different α-substituted fluoro(phenylsulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. [Copyright &y& Elsevier]

Subjects :: *PALLADIUM catalysts
*ACETIC acid
*ALKYLATION
*ALKYNES
*FLUORINATION
*SULFONES
*ETHERS

Language :: English
ISSN :: 00404039
Volume :: 50
Issue :: 52
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 45215842
Full Text :: https://doi.org/10.1016/j.tetlet.2009.09.126

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