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Tissue-mediated control of immunopathology in coeliac disease.
- Source :
-
Nature Reviews Immunology . Dec2009, Vol. 9 Issue 12, p858-870. 13p. 5 Diagrams, 1 Chart. - Publication Year :
- 2009
-
Abstract
- Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation--induced either by infectious agents or by gluten--is crucial for activating T cells and eliciting their tissue-destructive effector functions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 9
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 45430908
- Full Text :
- https://doi.org/10.1038/nri2670