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Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells
- Source :
-
Fertility & Sterility . Dec2009, Vol. 92 Issue 6, p2119-2121. 3p. - Publication Year :
- 2009
-
Abstract
- Insulin resistance on porcine granulosa cells was induced by wortmannin, the phosphatidylinositol-3-kinase inhibitor, and insulin signaling key molecules were investigated including glut4 and mitogen-activated protein kinase. Granulosa insulin resistance decreased glut4 expression but increased mitogen-activated protein kinase, indicating the cross talk between the metabolic and mitogenic pathways of insulin signaling in the ovary. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 92
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 45659383
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2009.06.019