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Single photon emission computed tomography/spiral computed tomography fusion imaging for the diagnosis of bone metastasis in patients with known cancer.
- Source :
-
Skeletal Radiology . Feb2010, Vol. 39 Issue 2, p147-153. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract Purpose  To evaluate single photon emission computed tomography (SPECT)/spiral computed tomography (CT) fusion imaging for the diagnosis of bone metastasis in patients with known cancer and to compare the diagnostic efficacy of SPECT/CT fusion imaging with that of SPECT alone and with SPECT  CT. Materials and methods  One hundred forty-one bone lesions of 125 cancer patients (with nonspecific bone findings on bone scintigraphy) were investigated in the study. SPECT, CT, and SPECT/CT fusion images were acquired simultaneously. All images were interpreted independently by two experienced nuclear medicine physicians. In cases of discrepancy, consensus was obtained by a joint reading. The final diagnosis was based on biopsy proof and radiologic follow-up over at least 1 year. Results  The final diagnosis revealed 63 malignant bone lesions and 78 benign lesions. The diagnostic sensitivity of SPECT, SPECT  CT, and SPECT/CT fusion imaging for malignant lesions was 82.5%, 93.7%, and 98.4%, respectively. Specificity was 66.7%, 80.8%, and 93.6%, respectively. Accuracy was 73.8%, 86.5%, and 95.7%, respectively. The specificity and accuracy of SPECT/CT fusion imaging for the diagnosis malignant bone lesions were significantly higher than those of SPECT alone and of SPECT  CT (Pâ2â=â9.855, Pâ=â0.002). The numbers of equivocal lesions were 37, 18, and 5 for SPECT, SPECT  CT, and SPECT/CT fusion imaging, respectively, and 29.7% (11/37), 27.8% (5/18), and 20.0% (1/5) of lesions were confirmed to be malignant by radiologic follow-up over at least 1 year. Conclusions  SPECT/spiral CT is particularly valuable for the diagnosis of bone metastasis in patients with known cancer by providing precise anatomic localization and detailed morphologic characteristics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03642348
- Volume :
- 39
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Skeletal Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 46781239
- Full Text :
- https://doi.org/10.1007/s00256-009-0764-0