Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction.

The article examines the origin of rate enhancement of flavin mono-nucleotide (FMN). It states that FMN reduction can be monitored as a pseudo-first-order reaction using single-turnover approaches. It suggests that the difference in observed rate between two near identical coenzymes is related to a vibrational mode present in the pentaerythritol tetranitrate reductase (PETNR) NADPH complex.