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Highly Enantioselective Rh-Catalyzed Hydrogenation of β,γ-Unsaturated Phosphonates with Chiral Ferrocene-Based Monophosphoramidite Ligands.
- Source :
-
Journal of Organic Chemistry . 12/4/2009, Vol. 74 Issue 23, p9191-9194. 4p. - Publication Year :
- 2009
-
Abstract
- An enantioselective synthesis of chiral alkylphosphonates bearing a β-stereogenic center, based on the Rh-catalyzed asymmetric hydrogenation of corresponding β-substituted β,γ-unsaturated phosphonates with a ferrocenebased monophosphoramidite ligand under the mild hydrogenation conditions, was developed, in which an ee value of up to 98% was obtained. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROGENATION
*PHOSPHONATES
*CHIRALITY
*FERROCENE
*LIGANDS (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 74
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 47138127
- Full Text :
- https://doi.org/10.1021/jo901619c