Endocrine Disruptive Effect of 3-Methyl-4-nitrophenol Isolated from Diesel Exhaust Particles in Hershberger Assay Using Castrated Immature Rats.

The article presents a study which investigates the endocrine disruptive effects of isolated 3-methyl-4-nitrophenol (PNMC) in diesel exhaust particles (DEP) through Hershberger assay in immature rats. It reveals that PNMC has increased the weights of the rats' seminal vesicles and their Cowper's glands, and the concentration of plasma testosterone. In addition, it has reduced the weight of the livers as well as the plasma follicle-stimulating hormone and luteinizing hormone of the subjects.