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Death-Associated Protein Kinase-Mediated Cell Death Modulated by Interaction with DANGER.
- Source :
-
Journal of Neuroscience . 1/6/2010, Vol. 30 Issue 1, p93-98. 6p. 4 Graphs. - Publication Year :
- 2010
-
Abstract
- Death-associated protein kinase (DAPK) is a key player in multiple cell death signaling pathways. We report that DAPK is regulated by DANGER, a partial MAB-21 domain-containing protein.DANGERbinds directly toDAPKand inhibitsDAPKcatalytic activity. DANGERdeficient mouse embryonic fibroblasts and neurons exhibit greater DAPK activity and increased sensitivity to cell death stimuli than do wild-type control cells. In addition, DANGER-deficient mice manifest more severe brain damage after acute excitotoxicity and transient cerebral ischemia than do control mice. Accordingly, DANGER may physiologically regulate the viability of neurons and represent a potential therapeutic target for stroke and neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 30
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 47596188
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.3974-09.2010