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Total synthesis of (−)-codonopsinol and (+)-2-epi codonopsinol via acid catalyzed amido cyclisation
- Source :
-
Tetrahedron . Feb2010, Vol. 66 Issue 6, p1202-1207. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: A short and stereoselective synthesis of (−)-codonopsinol 5 and its C-2 epimer 6 were accomplished from commercially available starting material d-1,5-gluconolactone, using acid mediated amido cyclisation as the key step. The inhibitory activitiy of these compounds against glucosidase and galactosidase has been studied. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 66
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 47641558
- Full Text :
- https://doi.org/10.1016/j.tet.2009.12.035