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Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
- Source :
-
Trends in Endocrinology & Metabolism . Feb2010, Vol. 21 Issue 2, p59-67. 9p. - Publication Year :
- 2010
-
Abstract
- GLP-1 (9-36)amide is the cleavage product of GLP-1(7-36) amide, formed by the action of diaminopeptidyl peptidase-4 (Dpp4), and is the major circulating form in plasma. Whereas GLP-1(7-36)amide stimulates glucose-dependent insulin secretion, GLP-1(9-36)amide has only weak partial insulinotropic agonist activities on the GLP-1 receptor, but suppresses hepatic glucose production, exerts antioxidant cardioprotective actions and reduces oxidative stress in vasculature tissues. These insulin-like activities suggest a role for GLP-1 (9-36)amide in the modulation of mitochondrial functions by mechanisms independent of the GLP-1 receptor. In this paper, we discuss the current literature suggesting that GLP-1(9-36)amide is an active peptide with important insulin-like actions. These findings have implications in nutrient assimilation, energy homeostasis, obesity, and the use of Dpp4 inhibitors for the treatment of diabetes. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10432760
- Volume :
- 21
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Trends in Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 47956316
- Full Text :
- https://doi.org/10.1016/j.tem.2009.11.007