Direct Electrochemistry of Drug Metabolizing Human Flavin-Containing Monooxygenase: Electrochemical Turnover of Benzydamine and Tamoxifen.

The article presents a study that describes the direct electrochemistry of human flavin-containing monooxygenase 3 (hFMO3) immobilized on glassy carbon (GC) and gold electrodes. The study analyzed the capability of the immobilized hFMO3 to oxygenate benzydamine and tamoxifen as well as differentiated it with solution studies. It states that benzydamine was metabolized by hFMO3 to its N-oxide while in tamoxifen there are three other metabolites generated by cytochromes P450.