Back to Search
Start Over
Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-d-sorbitol derivatives
- Source :
-
Bioorganic Chemistry . Apr2010, Vol. 38 Issue 2, p43-47. 5p. - Publication Year :
- 2010
-
Abstract
- Abstract: 3,6-Anhydro-1-(aryl or alkylamino)-1-deoxy-d-sorbitol derivatives have been prepared in four steps from isosorbide, a by-product from the starch industry. The inhibitory activities of these new compounds have been evaluated towards 13 glycosidases. A first lead-compound was identified, which inhibited β-N-acetylglucosaminidase from bovine kidney (82% inhibition at 1mM). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00452068
- Volume :
- 38
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Bioorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 48119906
- Full Text :
- https://doi.org/10.1016/j.bioorg.2009.12.002