Aldehyde- and Ketone-Induced Tandem Decarboxylation-Coupling (Csp3—Csp) of Natural α-Amino Acids and Alkynes.

An interesting aldehyde- and ketone-induced intermolecular tandem decarboxylation-coupling (Csp3Csp) catalyzed by copper with usc of natural α-amino acids as starting materials is developed under neutral conditions with the production of CO2 and H2O as the only byproducts. Various functionalized nitrogen-containing compounds were obtained by this method. In these processes, interesting regioselecsivites of the alkylation were observed, which has been rationalized by the relative stability of proposed resonance structures based on computation methods. [ABSTRACT FROM AUTHOR]