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Perifosine plus nutlin-3 combination shows a synergistic anti-leukaemic activity.

Authors :
Voltan, Rebecca
Celeghini, Claudio
Melloni, Elisabetta
Secchiero, Paola
Zauli, Giorgio
Source :
British Journal of Haematology. Mar2010, Vol. 148 Issue 6, p957-961. 5p. 1 Chart, 1 Graph.
Publication Year :
2010

Abstract

The article presents a research according to which combination of perifosine and nutlin-3 shows a synergistic anti-leukaemic activity. According to the researchers, use of the combination induced a significant increase of cytotoxicity in all leukaemic cell lines as compared to the cytotoxicity when perifosine alone is given.

Details

Language :
English
ISSN :
00071048
Volume :
148
Issue :
6
Database :
Academic Search Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
48346024
Full Text :
https://doi.org/10.1111/j.1365-2141.2009.08018.x