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Influence of backward bifurcation in a model of hepatitis B and C viruses
- Source :
-
Mathematical Biosciences . Apr2010, Vol. 224 Issue 2, p118-125. 8p. - Publication Year :
- 2010
-
Abstract
- Abstract: In the 1990s, liver transplantation for hepatitis B and C virus (HBV and HCV) related-liver diseases was a very controversial issue since recurrent infection of the graft was inevitable. Significant progress has been made in the prophylaxis and treatment of recurrent hepatitis B/C (or HBV/HCV infection) after liver transplantation. In this paper, we propose a mathematical model of ordinary differential equations describing the dynamics of the HBV/HCV and its interaction with both liver and blood cells. A single model is used to describe infection of either virus since the dynamics in-host (infected of the liver) are similar. Analyzing the model, we observe that the system shows either a transcritical or a backward bifurcation. Explicit conditions on the model parameters are given for the backward bifurcation to be present. Consequently, we investigate possible factors that are responsible for HBV/HCV infection and assess control strategies to reduce HBV/HCV reinfection and improve graft survival after liver transplantation. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00255564
- Volume :
- 224
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Mathematical Biosciences
- Publication Type :
- Periodical
- Accession number :
- 48406834
- Full Text :
- https://doi.org/10.1016/j.mbs.2010.01.002