Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy

Authors :: Yoshida-Hata, Natsuyo
Mitamura, Yoshinori
Oshitari, Toshiyuki
Namekata, Kazuhiko
Harada, Chikako
Harada, Takayuki
Yamamoto, Shuichi
Source :: Diabetes Research & Clinical Practice. Mar2010, Vol. 87 Issue 3, pe26-e28. 0p.
Publication Year :: 2010
Abstract: Abstract: SP1 mRNA was highly expressed in the epiretinal membranes of proliferative diabetic retinopathy (PDR), and the SP1 protein was mainly co-localized with vascular endothelial growth factor. SP1 might play an important role in the angiogenesis of PDR by regulating the promoter activity and expression of genes encoding angiogenesis-related factors. [Copyright &y& Elsevier]

Subjects :: *TRANSCRIPTION factors
*GENE expression
*MESSENGER RNA
*VASCULAR endothelial growth factors
*DIABETIC retinopathy
*NEOVASCULARIZATION
*PROMOTERS (Genetics)
*PATIENTS

Full Text Access

Tools