Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation...

Authors :: Hellstrom, Ann
Perruzzi, Carole
Ju, Meihua
Engstrom, Eva
Hard, Anna-Lena
Jun-Li Liu
Albertsson-Wikland, Kerstin Kerstin
Carlsson, Bjorn
Niklasson, Aimon
Sjodell, Lena
LeRoith, Derek
Senger, Donald R.
Smith, Lois E.H.
Source :: Proceedings of the National Academy of Sciences of the United States of America. 05/08/2001, Vol. 98 Issue 10, p5804. 5p. 4 Color Photographs, 6 Diagrams, 1 Graph.
Publication Year :: 2001
Abstract: Demonstrates that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor. Comparison with studies in premature infants; Blinding disease retinopathy of prematurity caused by IGF-I insufficiency.

Subjects :: *SOMATOMEDIN
*RETROLENTAL fibroplasia
*PREMATURE infant diseases

Language :: English
ISSN :: 00278424
Volume :: 98
Issue :: 10
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 4857384
Full Text :: https://doi.org/10.1073/pnas.101113998

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